The human 8-oxoguanine DNA glycosylase OGG1 is involved in base excision repair (BER). one of several DNA repair mechanisms that may counteract the effects of chemo- and radiation therapy for the treatment of cancer. We envisage that potent inhibitors of OGG1 may be found among the 9-alkyl-8-oxoguanines. Thus we explored synthetic routes to 8-oxoguanines and examined these as OGG1 inh... https://chefesquipmenters.shop/product-category/wire-shelving-kits/
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