Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a well-studied ER-associated degradation pathway. or ERAD. In contrast. very little is known about post-ER quality control mechanisms for damaged or misfolded integral membrane proteins. https://www.isbasvurusuyap.com/product-category/egg-rings/
The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress
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