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Anticancer effect of the antirheumatic drug leflunomide on oral squamous cell carcinoma by the inhibition of tumor angiogenesis

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Abstract Objectives Leflunomide (LEF) is a conventional synthetic disease-modifying antirheumatic drug and suppresses T-cell proliferation and activity by inhibiting pyrimidine synthesis using dihydroorotase dehydrogenase (DHODH); however. several studies have demonstrated that LEF possesses anticancer and antiangiogenic effects in some malignant tumors. Therefore. we investigated the... https://www.royaltyfurnitureandappliancers.shop/product-category/hybrid-mattresses/
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