The human membrane cofactor protein (MCP. CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b and serving as a cofactor for their cleavage. Recent data show that CD46 also plays a role in mediating acquired immune responses. https://unitedssports.shop/product-category/lacrosse-gloves/
Structure of the extracellular portion of CD46 provides insights into its interactions with complement proteins and pathogens.
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